The game features a vast open-world environment, set in the city of Liberty City, which is freely explorable. Players can engage in various activities, such as driving, shooting, and role-playing, using a wide range of vehicles, including cars, taxis, buses, bicycles, and boats. The game also includes a variety of side missions, known as "Strangers and Freaks" missions, which offer unique rewards and insights into the lives of Liberty City's inhabitants.