The critical reception of "The Movie 43" was overwhelmingly negative. The film holds a 7% approval rating on Rotten Tomatoes, with many critics calling it "a mess," "a disaster," and "a catastrophe." For instance, Peter Travers of Rolling Stone stated that the film was "a vomit-inducing, brain-cell-killing experience." The film was also a commercial failure, grossing only $47 million worldwide on a budget of $10 million.