The sequel takes place a few years after the events of the first film. Blade (Wesley Snipes) is forced to team up with a group of vampires, led by Nyssa Damaskinos (Leonor Varela), to take down a common enemy: the Reapers, a subspecies of vampires that threaten both human and vampire worlds. Morales's direction expertly balances the dark and suspenseful atmosphere of a vampire horror film with the over-the-top action sequences that fans of the franchise have come to expect.